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UMR_S Inserm - CEA - Université Grenoble Alpes

Bioscience and Bioengineering Laboratory (BGE)

Published on 2 August 2022
The "Bioscience and Bioengineering" Laboratory (UMR_S Inserm-CEA-UGA) is a research structure of the Interdisciplinary Research Institute of Grenoble. This laboratory brings together three teams (EDyP, Biomics and Gen&Chem) who have decided to implement large-scale strategies (proteomics, RNA interference, genetics, chemogenomics) in order to decipher the mechanisms that govern major cellular functions.

After having "dissected" cells for several decades, biologists now feel the need to integrate the knowledge acquired in order to analyze the properties of the systems studied in their entirety. Within the framework of research work that will be carried out without preconceived ideas, or by integrating less restrictive hypotheses, the approach of the "Bioscience and Bioengineering" (BGE) Laboratory will consist of finely characterizing biological systems by accumulating quantitative and temporal data, then disrupting these systems by genetic variations, chemical ligands, or stresses, in order to study the consequences for the cell. Thus, the BGE Laboratory is clearly positioned in the field of integrative and systems biology.

The identity of the Laboratory will be based on its activity at the cutting edge of innovation in the design, development and implementation of large-scale approaches. Particular importance will be given to the realization of developments that will make it possible to remove the technological barriers likely to limit the impact of the work that will be carried out. The challenges identified concern in particular the miniaturization and parallelization of approaches, the nature and quality of the data generated, and the mining and exploitation of these data. Because of the increasingly strong interactions between our institute and the DTBS (Department of Technologies for Biology and Health of the DRT), the BGE Laboratory will be particularly well positioned to carry out this type of project. Due to a lack of means in the fields of informatics and bioinformatics, the data generated by large-scale approaches are today largely under-exploited. The rise in power of these disciplines will be a clear objective of the BGE Laboratory, an objective that will be facilitated by the existence of significant internal strengths in these disciplines, and by close collaboration with Inria.

The research themes of the BGE Laboratory will be approached with the aim of increasing the knowledge of fundamental cellular mechanisms, with a strong desire to accompany these projects so as to enable the emergence of applications, in particular in the field of biology and health.