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Cellular cycle (Prostate Cancer)

Published on 20 August 2020

Project leader

Lamya Ghenim
Institut de Biosciences et Biotechnologies de Grenoble
Laboratoire Biologie à Grande Échelle
Équipe Biomics
17 avenue des Martyrs
38 054 Grenoble cedex 09
Phone: 33 (0)4 38 78 91 87

Project description

Lens-less video microscopy has made it possible to remove certain limits in observation of cell, allowing for the dynamic observation of cellular life, both microscopically and mesoscopically, over a wide field of view and over time periods ranging from a few days to several weeks. Furthermore, it enables to evaluate cell-to-cell variability using a very large number of cells. Based on this approach we recently started a new quantitative study of the human cell cycle (cell growth and proliferation) observing the kinetics of thousands of cells without any synchronization or labelling, over a wide field of (29.4 mm2) and over periods of up to several days (several cell cycles), and with a fairly rapid acquisition rate (5 min). Thus, we hope to better characterize the human cell cycle of both healthy and cancerous cell.

Publication (lens-less microscopy project)

Allier C, Morel S, Vincent R, Ghenim L, Navarro F, Menneteau M, Bordy T, Herve L, Cioni O, Gidrol X, Usson Y and Dinten JM
Imaging of dense cell cultures by multiwavelength lens-free video microscopy.
Cytometry A, 2017, 91(5): 433-442