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Biomicrotechnology and functional genomics (Biomics)

Published on 9 February 2023

Xavier Gidrol
Laboratoire Bioscience et Bioingénierie pour las santé
17 avenue des Martyrs
38 054 Grenoble
Phone: 33 (0)4 38 78 97 96

Biography of Xavier Gidrol

Julie Bourget
Phone: 33 (0)4 38 78 22 36 and 66 71
Fax: 33 (0)4 38 78 59 17

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Cell functions are influenced by the genetic program of cells but also through stimuli from the microenvironment: neighboring cells, extracellular matrix, soluble signal from stroma, physical constraints, etc. To discriminate the respective part of genetic and microenvironment on cell fate, it is necessary to control them at three dimensional scale (3D).

We use the potential of microfabrication and microfluidic to characterize genetic determinants which control the balance between proliferation and differentiation in the course of development and carcinogenesis in pancreas and skin. More specifically, we used large scale biology approaches (RNAi-based high content and throughput screening) on human cells grown in 3D (organoids, tumoroids, spheroids and organoids on chip) to characterize new biomarkers and therapeutic targets in oncology.

The team

Key words

Prostate cancer, breast cancer, interference RNA, 3D organoids, organ on chip, 3D bioprinting