Director

Xavier Gidrol Laboratoire Bioscience et Bioingénierie pour las santé Biomics CEA-Grenoble 17 avenue des Martyrs 38 054 Grenoble Phone: 33 (0)4 38 78 97 96 Biography of Xavier Gidrol Secretary: Julie Bourget Phone: 33 (0)4 38 78 22 36 and 66 71 Fax: 33 (0)4 38 78 59 17

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Presentation

Cell functions are influenced by the genetic program of cells but also through stimuli from the microenvironment: neighboring cells, extracellular matrix, soluble signal from stroma, physical constraints, etc. To discriminate the respective part of genetic and microenvironment on cell fate, it is necessary to control them at three dimensional scale (3D).

We use the potential of microfabrication and microfluidic to characterize genetic determinants which control the balance between proliferation and differentiation in the course of development and carcinogenesis in both mammary and prostatic glands. More specifically, we used functional genomics and phenomics approaches (RNAi-based high content and throughput screening) on human cells grown in 3D (organoid, spheroids, organs on chip) to characterize new biomarkers and therapeutic targets in oncology.





The team



Key words

Prostate cancer, breast cancer, interference RNA, 3D organoids, organ on chip, 3D bioprinting