We use the potential of microfabrication and microfluidic to characterize genetic determinants which control the balance between proliferation and differentiation in the course of development and carcinogenesis in pancreas and skin. More specifically, we used large scale biology approaches (RNAi-based high content and throughput screening) on human cells grown in 3D (organoids, tumoroids, spheroids and organoids on chip) to characterize new biomarkers and therapeutic targets in oncology.
The team
Key words
Prostate cancer, breast cancer, interference RNA, 3D organoids, organ on chip, 3D bioprinting