The objective of the BGE unit is to contribute to the improvement of human health in the fields of cancer, rare diseases and metabolic diseases through the discovery of molecular and cellular mechanisms of life, the identification of biomarkers of clinical interest, the selection of bioactive molecules and the development of innovative therapeutic strategies based on cellular and tissue engineering. The candidate will evaluate in particular the possibility of proposing a project in coherence with those of the Gen&Chem team focused on the mechanisms of regulation of intracellular signaling pathways and the identification of therapeutic targets in cancer or other pathologies related to the dysfunction of ubiquitin proteases. In addition, this team implements automated screening strategies for the selection of bioactive molecules for research or therapeutic purposes and develops bioinformatics and machine learning approaches to explore omic data and predict patient response to pharmacological treatments.

The candidate will benefit from a stimulating work environment and will be able to rely on the development of innovative cellular models (2D, 3D) or the use of genetic and preclinical live models (drosophila, mice...). He/she will have access to the IRIG's state-of-the-art platforms in imaging, proteomics, lipidomics, structural biology, automated high throughput screening or high information content by automated imaging (CMBA).

Link to the offer.