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The proteins modified by ubiquitin are doomed to autophagy. To identify deubiquitinases that negatively regulate that catabolic pathway, researchers from the Large Scale Biology Laboratory conducted a genetic screen in Drosophila. They show that the loss of function of one of these deubiquitinases causes blockage of the autophagy flow.
Thesis presented February 28, 2014 by Anne-Claire Jacomin
Thesis presented October 08, 2013 by Perrine Viargues. PhD thesis available as a pdf file.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.