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miRViz: Visualization of microRNA data

Published on 5 February 2019

Implied laboratory

Biomicrotechnology and functional genomics team (Biomics)
Interdisciplinary Research Institute of Grenoble (IRIG)

Scientific context

MicroRNAs are small RNAs that regulate the protein expression. Each microRNA targets the expression of a large number of protein coding genes. Similarly, many genes are targeted by several microRNAs. As major regulators of gene expression, microRNAs are involved in many biological processes and pathologies, particularly cancers.
The Biomics team of the BGE laboratory has developed a global approach to study all microRNAs from existing target prediction algorithms. Thus, for each of the algorithms used, a network of microRNAs was constructed in which each node corresponds to a microRNA, a link being drawn between two microRNAs if they share enough predicted targets. The study of these networks, on which microRNA expression data can be displayed, makes it possible, for example, to identify similar microRNAs involved in a pathology.

Description of the project

The miRViz project resulted in a software allowing to visualize the microRNA networks produced by the laboratory. This software includes the following features:
- display of several networks in parallel for easy comparison
- colorization of networks according to microRNA expression data (healthy tissues, diseased tissues ...)
- export of all or part of a network.

The latest version of miRViz is available on the PRABI web site.

Used technologies

Responsive web aplication developed with Java (Spring, JPA, JUnit), CSS / Javascript frameworks (Semantic-UI, React, D3JS…), Maven.