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FlexibleMeccano: Analysis of Nuclear Magnetic Resonance (NMR) data measured on disordered proteins

Published on 5 February 2019



Implied laboratory
Protein Dynamics and Flexibility By NMR group (FDP)
Institute of Structural Biology (IBS)
Scientific context
The FDP group studies disordered proteins, which have no defined tridimensional structure. The comprehension of these proteins is a significant scientific challenge because some of them are involved in pathologies such as cancer or Alzheimer’s disease.
In order to understand how these proteins work, the FDP group has developed the FlexibleMeccano software: this tool allows to predict the value of parameters which can be measured by Nuclear Magnetic Resonance (NMR) on these proteins. These predicted parameters can be then compared to the experimental data measured on the studied protein.
Description of the project
n order to be usable by a large number of users, it was important to complete the FlexibleMeccano software by appropriate and user-friendly graphical interfaces. It was the goal of the project managed by the GIPSE. The actual version of FlexibleMeccano can be downloaded on the IBS Web site.

Used technologies
Desktop application developed with Java (Netbeans Platform, Spring, AspectJ, JFreeChart, JUnit), Maven.
Publication
Ozenne V, Bauer F, Salmon L, Huang JR, Jensen MR, Segard S, Bernado P, Charavay C and Blackledge M
Flexible-meccano: A tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables.
Bioinformatics, 2012, 28(11): 1463-1470