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Publications de l'équipe

Publié le 21 février 2019


Andrieux A, Aubry L and Boscheron C
CAP-Gly proteins contribute to microtubule-dependent trafficking via interactions with the C-terminal aromatic residue of alpha-tubulin.
Small GTPases, 2019, 10(2): 138-45


Cortes S, Barette C, Beroud R, De Waard M and Schaack B
Functional characterization of cell-free expressed Kv1.3 channel using a voltage-sensitive fluorescent dye.
Protein Expression and Purification, 2018, 145: 94-99

Courtois G and Fauvarque MO
The many roles of ubiquitin in NF-ΚB signaling.
Biomedicines, 2018, 6(2): Article number 43

Crespo-Yanez X, Aguilar-Gurrieri C, Jacomin AC, Journet A, Mortier M, Taillebourg E, Soleilhac E, Weissenhorn W and Fauvarque MO
CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis.
PLoS Genetics, 2018, 14(6): e1007456

Jacomin AC, Taillebourg E and Fauvarque MO
Deubiquitinating enzymes related to autophagy: New therapeutic opportunities?
Cells, 2018, 7(8): 24

Mas L, Cieren A, Delphin C, Journet A and Aubry L
Calcium influx mediates the chemoattractant-induced translocation of the arrestin-related protein AdcC in Dictyostelium.
Journal of Cell Science, 2018, 131(19): UNSP jcs207951

Ouarné M, Bouvard C, Boneva G, Mallet C, Ribeiro J, Desroches-Castan A, Soleilhac E, Tillet E, Peyruchaud O and Bailly S
BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer.
Journal of Experimental & Clinical Cancer Research, 2018, 37(1): 209

Roelants C, Giacosa S, Pillet C, Bussat R, Champelovier P, Bastien O, Guyon L, Arnoux V, Cochet C and Filhol O
Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma.
Oncotarget, 2018, 9(53): 30066-30078

Soleilhac E, Brillet-Guéguen L, Roussel V, Prudent R, Touquet B, Dass S, Aci-Sèche S, Kasam V, Barette C, Imberty A, Breton V, Vantard M, Horvath D, Botté C, Tardieux I, Roy S, Maréchal E and Lafanechère L
Specific targeting of plant and apicomplexa parasite tubulin through differential screening using in silico and assay-based approaches.
International Journal of Molecular Sciences, 2018, 19(10): Article number 3085

Wallez Y, Bouillot S, Soleilhac E, Huber P, Attrée I and Faudry E
CLIQ-BID: A method to quantify bacteria-induced damage to eukaryotic cells by automated live-imaging of bright nuclei.
Scientific Reports, 2018, 8(1): Article number 5


Muller K, Courtois G, Ursini MV and Schwaninger M
New insight into the pathogenesis of cerebral small-vessel diseases.
Stroke, 2017, 48(2): 520-527

Pandey RR, Homolka D, Chen KM, Sachidanandam R, Fauvarque MO and Pillai RS
Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries.
PLoS Genetics, 2017, 13(8): e1006956


Do CV, Faouzi A, Barette C, Farce A, Fauvarque MO, Colomb E, Catry L, Berthier-Vergnes O, Haftek M, Barret R and Lomberget T
Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit.
Bioorganic and Medicinal Chemistry Letters, 2016, 26(1): 174-180

Gautheron J, Vucur M, Schneider AT, Severi I, Roderburg C, Roy S, Bartneck M, Schrammen P, Diaz MB, Ehling J, Gremse F, Heymann F, Koppe C, Lammers T, Kiessling F, Van Best N, Pabst O, Courtois G, Linkermann A, Krautwald S, Neumann UP, Tacke F, Trautwein C, Green DR, Longerich T, Frey N, Luedde M, Bluher M, Herzig S, Heikenwalder M and Luedde T
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
Nature Communications, 2016, 7: 11869

Jacomin AC, Fauvarque MO and Taillebourg E
A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila.
BMC Cell Biology, 2016, 17(1): 36

Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA and Pillai RS
PIWI slicing and EXD1 drive biogenesis of nuclear piRNAs from cytosolic targets of the mouse piRNA pathway.
Molecular Cell, 2016, 61(1): 138–152


Barette C, Soleilhac E, Charavay C, Cochet C and Fauvarque MO
Strength and specificity of the CMBA screening platform for bioactive molecules discovery.
Medecine Sciences (Paris), 2015, 31(4): 423-431

Brodin P, DelNery E and Soleilhac E
High Content Screening in chemical biology: Overview and main challenges.
Médecine Sciences, 2015, 31(2): 187-96

Desroches-Castan A, Quelard D, Demeunynck M, Constant JF, Dong C, Keramidas M, Coll JL, Barette C, Lafanechere L and Feige JJ
A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras.
Oncotarget, 2015, 6(7): 5382-5411

Homolka D, Pandey RR, Goriaux C, Brasset E, Vaury C, Sachidanandam R, Fauvarque MO and Pillai RS
PIWI slicing and RNA elements in precursors instruct directional primary piRNA biogenesis.
Cell Reports, 2015, 12(3): 418-428

Jacomin AC, Bescond A, Soleilhac E, Gallet B, Schoehn G, Fauvarque MO and Taillebourg E
The deubiquitinating enzyme UBPY is required for lysosomal biogenesis and productive autophagy in Drosophila.
PLoS One, 2015, 10(11): e0143078

Martinez A, Soleilhac E, Barette C, Prudent R, Gozzi GJ, Vassal-Stermann E, Pillet C, Pietro AD, Fauvarque MO and Lafanechere L
Novel synthetic pharmacophores inducing a stabilization of cellular microtubules.
Current Cancer Drug Targets, 2015, 15(1): 2-13

Murie C, Barette C, Button J, Lafanechère L and Nadon R
Improving detection of rare biological events in High-Throughput Screens.
Journal of Biomolecular Screening, 2015, 20(2): 230-241

Perrin J, Mortier M, Jacomin AC, Viargues P, Thevenon D and Fauvarque MO
The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila.
Journal of Innate Immunity, 2015, 7(1): 37-46

Senegas A, Gautheron J, Gentil Dit Maurin A and Courtois G
IKK-related genetic diseases: Probing NF-κB functions in humans and other matters.
Cellular and Molecular Life Sciences, 2015, 72(7): 1275-1287


Eguether T, Ermolaeva MA, Zhao Y, Bonnet MC, Jain A, Pasparakis M, Courtois G and Tassin AM
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
Nature Communications, 2014, 5: 4585

Engel E, Viargues P, Mortier M, Taillebourg E, Couté Y, Thevenon D and Fauvarque MO
Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome.
Cell Communication and Signaling, 2014, 12(1): 41

Fauvarque MO
Small flies to tackle big questions: Assaying complex bacterial virulence mechanisms using Drosophila melanogaster.
Cellular Microbiology, 2014, 16(6): 824-833

Murie C, Barette C, Lafanechère L and Nadon R
Control-Plate Regression (CPR) normalization for High-Throughput Screens with many active features.
Journal of Biomolecular Screen, 2014, 19(5): 661-671

Taillebourg E, Schneider DS and Fauvarque MO
The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.
Journal of Innate Immunity, 2014, 6(5): 632-638

Weissenhorn W and Fauvarque MO
A small switch has a large effect on autophagy.
Structure, 2014, 22(1): 1-2


Boussouar A, Barette C, Nadon R, Saint-Léger A, Broucqsault N, Ottaviani A, Firozhoussen A, Lu Y, Lafanechère L, Gilson E, Magdinier F and Ye J
Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells.
Molecular Therapy. Nucleic Acids, 2013, 2: e116

Murie C, Barette C, Lafanechère L and Nadon R
Single assay-wide variance experimental (SAVE) design for high-throughput screening.
Bioinformatics, 2013, 29(23): 3067-3072

Prudent R, Soleilhac E, Barette C, Fauvarque MO and Lafanechère L
Phenotypic screens or one stone to kill two birds: Discover the target and its pharmacological regulator.
Médecine Sciences, 2013, 29(10): 897-905

Prudent R, Vassal-Stermann E, Nguyen CH, Mollaret M, Viallet J, Desroches-Castan A, Martinez A, Barette C, Pillet C, Valdameri G, Soleilhac E, Di Pietro A, Feige JJ, Billaud M, Florent JC and Lafanechère L
Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.
British Journal of Pharmacology, 2013, 168: 673–68


de Bentzmann S, Giraud C, Bernard CS, Calderon V, Ewald F, Plesiat P, Nguyen C, Grunwald D, Attree I, Jeannot K, Fauvarque MO and Bordi C
Unique biofilm signature, drug susceptibility and decreased virulence in Drosophila through the Pseudomonas aeruginosa two-component system PprAB.
PLoS Pathogens, 2012, 8(11): e1003052

Camara D, Bisanz C, Barette C, Van Daele J, Human E, Barnard B, Van Der Straeten D, Stove CP, Lambert WE, Douce R, Maréchal E, Birkholtz LM, Cesbron-Delauw MF, Dumas R and Rébeillé F
Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine
Journal of Biological Chemistry, 2012, 287(26): 22367-22376

Fais S and Fauvarque MO
TM9 and cannibalism: How to learn more about cancer by studying amoebae and invertebrates.
Trends in Molecular Medicine, 2012, 18(1): 4-5

Lo E, Soleilhac E, Martinez A, Lafanechère L and Nadon R
Intensity quantile estimation and mapping-a novel algorithm for the correction of image non-uniformity bias in HCS data.
Bioinformatics, 2012, 28(20): 2632-2639

Prudent R, Vassal-Stermann E, Nguyen CH, Pillet C, Martinez A, Prunier C, Barette C, Soleilhac E, Filhol O, Beghin A, Valdameri G, Honore S, Aci-Seche S, Grierson D, Antonipillai J, Li R, Di Pietro A, Dumontet C, Braguer D, Florent JC, Knapp S, Bernard O and Lafanechere L
Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.
Cancer Research, 2012, 72(17): 4429-4439

Sampson CJ, Valanne S, Fauvarque MO, Hultmark D, Rämet M and Williams MJ
The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42.
Developmental and Comparative Immunology, 2012, 38(1): 160–168

Taillebourg E, Gregoire I, Viargues P, Jacomin AC, Thevenon D, Faure M and Fauvarque MO
The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.
Autophagy, 2012, 8(5): 767-779


Fauvarque MO and Williams MJ
Drosophila cellular immunity: A story of migration and adhesion.
Journal of Cell Science, 2011, 124(Pt 9): 1373-1382

Moucadel V, Prudent R, Sautel CF, Teillet F, Barette C, Lafanechere L, Receveur-Brechot V and Cochet C
Antitumoral activity of allosteric inhibitors of Protein kinase CK2.
Oncotarget, 2011, 2(12): 997-1010


Gilquin B, Taillebourg E, Cherradi N, Hubstenberger A, Gay O, Merle N, Assard N, Fauvarque MO, Tomohiro S, Kuge O and Baudier J
The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membrane.
Molecular and Cellular Biology, 2010, 30(8): 1984-1996

Lopez-Ramos M, Prudent R, Moucadel V, Sautel CF, Barette C, Lafanechere L, Mouawad L, Grierson D, Schmidt F, Florent JC, Filippakopoulos P, Bullock AN, Knapp S, Reiser JB and Cochet C
New potent dual inhibitors of CK2 and Pim kinases: Discovery and structural insights.
FASEB Journal, 2010, 24(9): 3171-3185

Soleilhac E, Nadon R and Lafanechère L
High-content screening for the discovery of pharmacological compounds: Advantages, challenges and potential benefits of recent technological developments.
Expert Opinion on Drug Discovery, 2010, 5: 135-144


Hoang TM, Favier B, Valette A, Barette C, Nguyen CH, Lafanechère L, Grierson DS, Dimitrov S and Molla A
Benzo[e]pyridoindoles, novel inhibitors of the aurora kinases.
Cell Cycle, 2009, 8(5): 765-772

Thevenon D, Engel E, Avet-Rochex A, Gottar M, Bergeret E, Tricoire H, Benaud C, Baudier J, Taillebourg E and Fauvarque MO
The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling.
Cell Host and Microbe, 2009, 6(4): 309-320


Alibaud L, Kohler T, Coudray A, Prigent-Combaret C, Bergeret E, Perrin J, Benghezal M, Reimmann C, Gauthier Y, van Delden C, Attree I, Fauvarque MO and Cosson P
Pseudomonas aeruginosa virulence genes identified in a Dictyostelium host model.
Cellular Microbiology, 2008, 10(3): 729-740

Bergeret E, Perrin J, Williams M, Grunwald D, Engel E, Thevenon D, Taillebourg E, Bruckert F, Cosson P and Fauvarque MO
TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis.
Journal of Cell Science, 2008, 121(Pt 20): 3325-3334

Engel E, Thevenon D, Taillebourg E and Fauvarque MO
Regulation of NF κ B paths in ubiquitin specific proteases.
Bulletin du Cancer, 2008, 95: S31-S31

Prudent R, López-Ramos M, Moucadel V, Barette C, Grierson D, Mouawad L, Florent JC, Lafanechère L, Schmidt F and Cochet C
Salicylaldehyde derivatives as new protein ikinase CK2 inhibitors.
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008, 1780(12): 1412-1420

Prudent R, Moucadel V, Lopez-Ramos M, Aci S, Laudet B, Mouawad L, Barette C, Einhorn J, Einhorn C, Denis JN, Bisson G, Schmidt F, Roy S, Lafanechère L, Florent JC and Cochet C
Expanding the chemical diversity of CK2 inhibitors.
Molecular and Cellular Biochemistry, 2008, 316(1-2): 71-85


Avet-Rochex A, Perrin J, Bergeret E and Fauvarque MO
Rac2 is a major actor of Drosophila resistance to Pseudomonas aeruginosa acting in phagocytic cells.
Genes to Cells, 2007, 12: 1193-204

Barette C
La démarche qualité pour le criblage automatisé In Chemogénomique, des petites molécules pour explorer le vivant, Edited by Maréchal E, Roy S and Lafanechère L. EDP Sciences, Grenoble Sciences, 2007, pp 81-87

Fonrose X, Ausseil F, Sans-Soleilhac E, Masson V, David B, Pouny I, Cintrat JC, Rousseau B, Barette C, Massiot G and Lafanechère L
Parthenolide inhibits tubulin carboxypeptidase activity.
Cancer Research, 2007, 67(7): 3371-3378

Laudet B, Barette C, Dulery V, Renaudet O, Dumy P, Metz A, Prudent R, Deshiere A, Dideberg O, Filhol O and Cochet C
Structure-based design of small peptide inhibitors of protein-kinase CK2 subunit interaction.
Biochemical Journal, 2007, 408(3): 363-373

2006 et antérieur 

Anselme C, Vallier A, Balmand S, Fauvarque MO and Heddi A
Host PGRP gene expression and bacterial release in endosymbiosis of the weevil Sitophilus zeamais.
Applied and Environmental Microbiology, 2006, 72(10): 6766-6772

Benghezal M, Fauvarque MO, Tournebize R, Froquet R, Marchetti A, Bergeret E, Lardy B, Klein G, Sansonetti P, Charette SJ and Cosson P
Specific host genes required for the killing of Klebsiella bacteria by phagocytes.
Cellular Microbiology, 2006, 8(1): 139-148

Vassal E, Barette C, Fonrose X, Dupont R, Sans-Soleilhac E and Lafanechère L
Miniaturization and validation of a sensitive multi-parametric cell-based assay for the concomitant detection of microtubule-destabilizing and microtubule-stabilizing agents.
Journal of Biomolecular Screening, 2006, 11: 377-389

Avet-Rochex A, Bergeret E, Attree I, Meister M and Fauvarque MO
Suppression of Drosophila cellular immunity by directed expression of the ExoS toxin GAP domain of Pseudomonas aeruginosa.
Cellular Microbiology, 2005, 7: 799-810

Raymond K, Bergeret E, Avet-Rochex A, Griffin-Shea R and Fauvarque MO
A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis.
Journal of Cell Science, 2004, 117(13): 2777-2789

Sans-Solheihac E, Barette C, Wieczorek S, Roy S, Maréchal E and Lafanechère L
Criblages phénotypiques et "génétique chimique directe" : une approche innovante pour la découverte de molécules bio-actives et/ou de candidats médicaments.
Spectra Analyse, 2003, 32: 33-37

Fauvarque MO, Bergeret E, Chabert J, Dacheux D, Satre M and Attree I
Role and activation of type III secretion system genes in Pseudomonas aeruginosa-induced Drosophila killing.
Microbial Pathogenesis, 2002, 32(6): 287-295

Raymond K, Bergeret E, Dagher MC, Breton R, Griffin-Shea R and Fauvarque MO
The Rac GTPase-activating protein RotundRacGAP interferes with Drac1 and Dcdc42 signalling in Drosophila melanogaster.
Journal of Biological Chemistry, 2001, 276(38):35909-16